Engineered cartilage regenerates joints
Human articular cartilage defects can be treated with nasal septum cells. Researchers at the University and the University Hospital of Basel report that cells taken from the nasal septum are able to adapt to the environment of the knee joint and can thus repair articular cartilage defects. The nasal cartilage cells’ ability to self-renew and adapt to the joint environment is associated with the expression of so-called HOX genes. The scientific journal Science Translational Medicine has published the research results together with the report of the first treated patients.
K. Pelttari, B. Pippenger, M. Mumme, S. Feliciano, C. Scotti, P. Mainil-Varlet, A. Procino, B. von Rechenberg, T. Schwamborn, M. Jakob, C. Cillo, A. Barbero, I. Martin. Adult human neural crest-derived cells for articular cartilage repair. Science Translational Medicine, 2014; 6 (251): 251ra119 DOI: 10.1126/scitranslmed.3009688
Articular cartilage replaced: MRI of defect tissue site before (left) and four months after (right) transplantation. Credit: University of Basel, Department of Biomedicine